Systemic Hypoxemia Induces Cardiomyocyte Hypertrophy and Right Ventricular Specific Induction of Proliferation.

Jaslyn Johnson,Yijun Yang,Zilin Bian,Giana Schena,Yijia Li,Xiaoying Zhang,Deborah M Eaton,Polina Gross,Alexandra Angheloiu,Arshadullah Shaik,Michael Foster,Remus Berretta,Hajime Kubo,Sadia Mohsin, Ying Tian,Steven R Houser

Circulation research（2023）

Cited 5|Views34

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Abstract

Systemic hypoxia induces a global hypertrophic stress response that was associated with increased RV proliferation, and while LV myocytes did not show increased proliferation, our results minimally confirm previous reports that hypoxia can induce cardiomyocyte cell cycle activity in vivo.

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Key words

cell proliferation,cytokinesis,hypoxia,myocytes, cardiac,neovascularization, pathologic,ventricular remodeling

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