Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer.

Zheng Jin,Fei Peng,Chao Zhang,Shuang Tao,Damo Xu,Zhenhua Zhu

Heliyon（2023）

引用 4|浏览9

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摘要

Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromosomes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.

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关键词

ATP, adenosine triphosphate,BTC, biliary tract cancer,CPC, chromosomal passenger complex,CTL, cytotoxic T lymphocyte,Cancer,Cdk1, cyclin-dependent kinase 1,DLG5, discs large MAGUK scaffold protein 5,EMT, epithelial-mesenchymal transition,Expression,FoxM1, forkhead box protein M1,GC, gastric cancer,GEM, gemcitabine,Gli2, glioma-associated oncogene 2,HLA, human leukocyte antigen,HNMT, head-and-neck malignant tumor,IRF, interferon regulatory factor,JAK, Janus kinase,KIF20A,KIF20A, kinesin family member 20A,LP, long peptide,MHC I, major histocompatibility complex I,MKlp2, mitotic kinesin-like protein 2,Mad2, mitotic arrest deficient 2,OS, overall survival,PBMC, peripheral blood mononuclear cell,Plk1, polo-like kinase 1,Regulating mechanisms,Therapeutic target,circRNA, circular RNA,miRNA, microRNA

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