STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity.

bioRxiv : the preprint server for biology(2023)

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摘要
STAT3 is critical for hematopoietic activity and hematopoietic stem cell maintenance in non-inflammatory conditionsSTAT3 has a cell-intrinsic role in the suppression of interferon signaling and myeloid-skewed transcription in hematopoietic stem cells.
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