HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells.

bioRxiv : the preprint server for biology（2023）

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摘要

Loss of HOPS-mediated lysosomal fusion indirectly blocks apical actin clearing and ciliogenesis in polarized epithelia by trapping Rab19 on late endosomes and depleting Rab19 from the basal body.

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