Identification of Putative Drug Targets in Highly Resistant Gram-Negative Bacteria; and Drug Discovery Against Glycyl-tRNA Synthetase as a New Target.

Sepideh Fereshteh,Narjes Noori Goodarzi,Hourieh Kalhor,Hamzeh Rahimi,Seyed Mahmoud Barzi,Farzad Badmasti

Bioinformatics and biology insights（2023）

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摘要

The results of this study provide 6 common putative new drug targets against 4 highly resistant and Gram-negative bacteria. Moreover, we presented 5 different hit compounds against GlyQ protein as a novel therapeutic target. However, further in vitro and in vivo studies are needed to explore the bactericidal effects of proposed hit compounds against these superbugs.

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关键词

GlyQ protein,Gram-negative bacteria,StreptomeDB library,computer-aided drug discovery,virtual screening

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