Endogenous sex hormones modulate the analgesic effect of tramadol in lean and high fat diet-induced obese Wistar rats: a preclinical molecular approach.
Neuroendocrinology（2023）
Abstract
The analgesic effect of tramadol was more pronounced in male rats compared to female rats. The analgesic effect of tramadol was more marked in lean rats compared to obese rats. Additional research to elucidate obesity-induced endocrine changes and the mechanisms driving sex hormones in pain perception is needed to foster future interventions to reduce disparities in pain.
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