Expression pattern of hypoxia-related genes in odontogenic cysts.

Bilal Ege,Esra Bozgeyik,Seyma Bayazıt,Ibrahim Bozgeyik,Zozan Erdogmus,Mahmut Koparal

Archives of oral biology（2023）

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摘要

Odontogenic cysts were found to have higher expression of HIF1A and HIF1A-AS1, which may be related to the increased hypoxia in these lesions. In addition, PI3K/Akt signaling may be stimulated by increased PIK3CA and decreased PTEN expression, which promote cell survival and support the mechanism of cyst formation.

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关键词

Dentigerous cyst,HIF1A,Hypoxia,Odontogenic keratocyst,Radicular cyst

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