Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy.

Yutaka Fukaya,Toshimi Kimura,Yukihiro Hamada,Kenichi Yoshimura,Hiroaki Hiraga,Yuki Yuza,Atsushi Ogawa,Junichi Hara,Katsuyoshi Koh,Atsushi Kikuta,Yuhki Koga,Hiroshi Kawamoto

Frontiers in oncology（2023）

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摘要

https://dbcentre3.jmacct.med.or.jp/JMACTR/App/JMACTRS06/JMACTRS06.aspx?seqno=2363, identifier JMA-IIA00078 and https://dbcentre3.jmacct.med.or.jp/JMACTR/App/JMACTRS06/JMACTRS06.aspx?seqno=2782, identifier JMA-IIA00097.

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关键词

glucarpidase,methotrexate - adverse effects,pharmacodynamics,pharmacokinetics,safety

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