CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.

Jitske van den Bulk,Manon van der Ploeg,Marieke E Ijsselsteijn,Dina Ruano,Ruud van der Breggen,Rebekka Duhen,Koen C M J Peeters,Arantza Fariña-Sarasqueta,Els M E Verdegaal,Sjoerd H van der Burg,Thomas Duhen,Noel F C C de Miranda

Journal for immunotherapy of cancer（2023）

引用 6|浏览53

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摘要

Coexpression of CD103 and CD39 is characteristic of neoantigen-specific CD8 T cells in MMR-proficient CRCs with low mutation burden. The exploitation of these subsets in the context of adoptive T cell transfer or engineered T cell receptor therapies is a promising avenue to extend the benefits of immunotherapy to an increasing number of CRC patients.

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关键词

Antigens,CD8-Positive T-Lymphocytes,Gastrointestinal Neoplasms,Immunotherapy,Lymphocytes, Tumor-Infiltrating

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