IL-17A facilitates type 2 inflammation in a modified eosinophilic chronic rhinosinusitis mouse model.

Haotian Wu,Zhiyuan Wang,Xia Li,Xiaohong Chen,Yue Li,Weiqiang Huang,Lihong Chang,Gehua Zhang

International forum of allergy & rhinology（2023）

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摘要

OVA sensitization and unilateral nasal tamponade, combined with SEB and OVA alternate nasal instillation (OVA + SEB group), could be used to construct a more typical ECRS mouse model in which IL-17A enhanced the expression of type 2 cytokines and eosinophil infiltration.

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关键词

IL-17A,eosinophilic chronic rhinosinusitis,mouse model,type 2 inflammation

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