Sindbis Virus in Iran and Adjacent Countries- A Systematic Review

Background: One of the Arboviral diseases mostly transmitted by mosquitoes of the family Culicidae is Sindbis virus (SINV). Conduction of studies on the distribution of the distribution of vector-borne viruses and their prevalence has become very important in recent years. The present study aimed to investigate the status of this virus in Iran and adjacent countries by reviewing published literature.Methods: Various databases including Magiran, IranDoc, Civilica, Jihad Daneshgahi Scientific Information Center (SID), Web of Science, Scopus, Science Direct, Google Scholar, and PubMed were investigated in both Persian and English languages.Findings: The results indicated the evidence of the presence of the virus in Iran and eight neighboring countries. Evolutionary analysis and alignment of registered sequences in GenBank showed 100% similarity of sequences registered from Iran with a number of sequences registered from Armenia and Russia.Conclusion: The current review of the studies and sequences registered in GenBank shows the presence of the virus in Iran and other countries in the region. So far, very few studies have been carried out on the epidemiology of this virus in Iran and the Middle East. Further studies in different parts of these regions are recommended.