Determining the structural ensembles of disordered RNA and proteins using an integrated approach

Much of the proteome and transcriptome lacks secondary and tertiary structure but still maintains important function.Not conforming to a single well-defined structure affords macromolecules greater flexibility, as seen for instance in the nuclear pore complex, histone tails, and noncoding RNA scaffolds.Multivalent, dynamic interactions between disordered proteins and RNA are also critical toward the formation of phase separated biomolecular condensates, which have been shown to have critical roles in cellular physiology.