Solvent induced conformational polymorphism

The fact that the polymorphic outcome of crystallization is the result of the interplay between the relative thermodynamic stability and nucleation kinetics is well known. This paper presents the synthesis of 2,5-bis(3-bromophenyl)furan (MBPF), for which three polymorphic structures were obtained. The studies included: investigations of three polymorphic structures of this compound using single crystal X-ray diffraction, UV-Vis spectroscopy, circular dichroism spectroscopy, and theoretical approaches. The most important experimental result is the solvent effect on the MBPF conformation stability and in consequence on the crystal growth of the metastable phase.