Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2.

Hou-Zhi Yang,Runbei Dong,Yutao Jia,Yuqiao Li,Gan Luo,Tianhao Li,Yao Long,Shuang Liang,Shanshan Li,Xin Jin,Tianwei Sun

Pharmaceutical biology（2023）

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摘要

These findings demonstrated that MOR treatment promoted osteoblastogenesis and ameliorated glucocorticoid-induced OP by targeting SGLT2, which may provide therapeutic potential in managing glucocorticoid-induced OP.

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关键词

MC3T3-E1 cells,SGLT2,glucose pockets,molecular docking,zebrafish

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