The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report.

Kate L Harkness,Trisha Chakrabarty,Sakina J Rizvi,Raegan Mazurka,Lena Quilty,Rudolf Uher,Roumen V Milev,Benicio N Frey,Sagar V Parikh,Jane A Foster,Susan Rotzinger,Sidney H Kennedy,Raymond W Lam

Canadian journal of psychiatry. Revue canadienne de psychiatrie（2023）

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摘要

We identify emotional maltreatment as a specific early exposure that places patients at the greatest risk for nonremission following pharmacological treatment. Further, we suggest that anhedonia is a key symptom domain driving nonremission in patients with particular maltreatment histories.

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关键词

anhedonia,antidepressant treatment,childhood maltreatment,major depression

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