Immunogenicity of an adjuvanted SARS-CoV-2 trimeric S-protein subunit vaccine (SCB-2019) in SARS-CoV-2-naïve and exposed individuals in a phase 2/3, double-blind, randomized study

Erik Buntinx,Leonardo Brochado,Charissa Borja-Tabora,Charles Y Yu,Edison R Alberto,May Emmeline B Montellano,Josefina C Carlos,Leonardo Bautista Toloza,Maya Hites,George Siber,Ralf Clemens,Donna Ambrosino,Haijing Qin,Hui Ling Chen,Htay Htay Han,Branda Hu,Ping Li,Carmen Baccarini,Igor Smolenov

Vaccine（2023）

引用 5|浏览13

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摘要

•SCB-2019 is a protein subunit vaccine candidate against COVID-19.•SCB-2019 contains the SARS-CoV-2 spike protein adjuvanted with CpG-1018/alum.•A single dose of SCB-2019 was immunogenic in SARS-CoV-2-exposed individuals.•Two doses are required to induce immune response in SARS-CoV-2-naïve individuals.•SCB-2019 induced cross-reactive neutralizing antibodies to SARS-CoV-2 variants.

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关键词

COVID-19,SARS-CoV-2,SCB-2019,Vaccine,Immunogenicity,Cell-mediated immunity

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