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Evaluation of cross-protection between S. Pneumoniae serotypes 35B and 29 in a mouse model

Ellie Kim,Jian He,Robin M Kaufhold,Debra McGuinness,Patrick McHugh,Denise Nawrocki,Jinfu Xie,Julie M Skinner

Vaccine（2023）

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Abstract
Pneumococcal conjugate vaccines (PCVs) have reduced vaccine-type pneumococcal disease but in turn have also resulted in replacement with non-vaccine serotypes. One such serotype, 35B, a multidrug resistant type, has been associated with an increase in disease.
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Key words
Pneumococcal conjugate vaccines,PCV,ST35B,ST29,IT challenge,Mouse study,V116,OPA,ELISA
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