Protein arginine deiminase 4 inactivates tissue factor pathway inhibitor-alpha by enzymatic modification of functional arginine residues.

M Christella L G D Thomassen,Bryan R C Bouwens,Kanin Wichapong,Dennis P Suylen,Freek G Bouwman,Tilman M Hackeng,Rory R Koenen

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

Full-length TFPIα is sensitive to citrullination by PAD4, which causes loss of factor Xa inhibition. This process may play a role in the increased thrombosis risk associated with inflammation.

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关键词

blood coagulation,citrullination,extracellular traps,neutrophils,thromboinflammation

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