Total Synthesis of Vilmoraconitine.
Journal of the American Chemical Society(2023)
摘要
Vilmoraconitine belongs to one of the most complex skeleton types in the C-diterpenoid alkaloids, which architecturally features an unprecedented heptacyclic core possessing a rigid cyclopropane unit. Here, we report the first total synthesis of vilmoraconitine relying on strategic use of efficient ring-forming reactions. Key steps include an oxidative dearomatization-induced Diels-Alder cycloaddition, a hydrodealkenylative fragmentation/Mannich sequence, and an intramolecular Diels-Alder cycloaddition.
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total synthesis
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