High serum neurofilament light chain levels correlate with brain atrophy and physical disability in multiple sclerosis.

Arabella Buchmann,Lukas Pirpamer,Daniela Pinter,Margarete Voortman,Birgit Helmlinger,Alexander Pichler,Aleksandra Maleska Maceski,Pascal Benkert,Gerhard Bachmaier,Stefan Ropele,Markus Reindl,David Leppert,Jens Kuhle,Christian Enzinger,Michael Khalil

European journal of neurology（2023）

Cited 2|Views29

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Abstract

Already single time point elevation of sNfL has a distinct effect on brain volume changes over a short-term period, and repeated high levels of sNfL indicate accumulating physical disability. Serial assessment of sNfL may provide added value in the clinical management of pwMS.

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Key words

atrophy,disability,multiple sclerosis,neurodegeneration,neurofilament

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