Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras -driven pancreatic cancer model.

Morgan T Walcheck,Patrick B Schwartz,Noah D Carrillo, Kristina A Matkowsky,Manabu Nukaya, Christopher A Bradfield,Sean M Ronnekleiv-Kelly

bioRxiv : the preprint server for biology（2023）

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摘要

These findings show the loss of AHR results in heightened -induced PanIN formation, through modulation of immune cells within the pancreatic tumor microenvironment.

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