Associations Between Plasma Klotho with Renal Function and Cerebrospinal Fluid Amyloid-β Levels in Alzheimer's Disease: The Chongqing Ageing & Dementia Study.

Jun-Rong Ren,Zhen Wang,Yuan Cheng,Chen-Yang He,Jie-Ming Jian,Dong-Yu Fan,Ying-Ying Shen,Dong-Wan Chen,Hui-Yun Li,Xu Yi,Gui-Hua Zeng,Cheng-Rong Tan,An-Yu Shi,Li-Yong Chen, Qing-Xiang Mao,Yan-Jiang Wang,Jun Wang

Journal of Alzheimer's disease : JAD（2023）

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摘要

Renal function impacts brain Aβ metabolism via the kidney-brain crosstalk, in which the plasma Klotho may be involved as a mediator. Targeting Klotho to regulate the kidney-brain crosstalk provides potential therapeutic approaches for AD.

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关键词

Alzheimer’s disease,Klotho,amyloid-β,estimated glomerular filtration rate,kidney-brain crosstalk

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