Cerebrospinal Fluid Panel of Synaptic Proteins in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

Emma van den Berg,Johanna Nilsson,Iris Kersten,Gunnar Brinkmalm,Anna M de Kort,Catharina J M Klijn,Floris H B M Schreuder,Lieke Jäkel,Johan Gobom,Erik Portelius,Henrik Zetterberg,Ann Brinkmalm,Kaj Blennow,H Bea Kuiperij,Marcel M Verbeek

Journal of Alzheimer's disease : JAD（2023）

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摘要

In contrast to AD, synaptic CSF biomarkers were found to be largely unchanged in CAA. Moreover, concomitant AD pathology in CAA is associated with abnormal synaptic protein levels. Impaired synaptic function in AD was confirmed in this independent cohort. Our findings support an apparent differential involvement of synaptic dysfunction in CAA and AD and may reflect distinct pathological mechanisms.

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关键词

Alzheimer’s disease,biomarkers,cerebral amyloid angiopathy,cerebrospinal fluid,synaptic pathology

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