Hypoxia-induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase-1 in multiple myeloma.

Ko Abe,Sho Ikeda,Miho Nara,Akihiro Kitadate,Hiroyuki Tagawa,Naoto Takahashi

Cancer medicine（2023）

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摘要

These results suggest that the hypoxia-ROS-HMOX1 axis and hypoxia-induced MafB may be important mechanisms of proteasome inhibitor resistance in hypoxic microenvironments.

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关键词

heme oxygenase-1,hypoxia,multiple myeloma,reactive oxygen species,side population

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