Prominent Staining of MYCN Immunohistochemistry Predicts a Poor Prognosis in MYCN Non-Amplified Neuroblastoma.

Manli Zhao,Weizhong Gu,Fei Liu,Lihua Yu,Yan Shu,Lei Liu,Jiahui Hu,Yang Liu,Hongfeng Tang,Jianhua Mao

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society（2023）

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摘要

MYCN protein overexpression was not only a sensitive and specific marker for gene amplification, but also a marker of poor prognosis in patients without amplification. However, MYCN protein expression was not always consistent before and after treatment.

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关键词

FISH,MYCN,biomarker,chemotherapy,immunohistochemistry,neuroblastoma

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