CRISPR/Cas9-mediated knockout of NlCYP6CS1 gene reveals its role in detoxification of insecticides in Nilaparvata lugens (Hemiptera: Delphacidae).

Yan-Chao Zhang,Yang Gao,Wen-Nan Ye,Yu-Xuan Peng,Kun Yan Zhu,Cong-Fen Gao

Pest management science（2023）

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摘要

Our study demonstrates the effect of functional deletion of NlCYP6CS1 on multiple insecticide resistance in N. lugens. For the first time, we applied CRISPR/Cas9 system to reveal the mechanism of insecticide resistance in N. lugens, which may shed light on similar studies in other hemipteran insects. © 2023 Society of Chemical Industry.

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关键词

CRISPR/Cas9,Nilaparvata lugens,NlCYP6CS1,cytochrome P450,insecticide resistance

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