Metabolomic and transcriptomic response to imatinib treatment of gastrointestinal stromal tumour in xenograft-bearing mice

Szymon Macioszek,Danuta Dudzik,Rafał Bartoszewski,Tomasz Stokowy,Diether Lambrechts,Bram Boeckx,Agnieszka Wozniak,Patrick Schöffski,Michał J Markuszewski

Translational Oncology（2023）

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摘要

•Imatinib treatment influences both the metabolome and transcriptome of GIST cell•Changes in purine, pyrimidine, butanoate, and amino acid metabolism were detected•Expression of kinase activity, immune response, and purine biosynthesis-related genes were altered•Transcriptomic results support insights gained from the metabolomic study

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关键词

Metabolomics,Transcriptomics,Imatinib,GIST,purines,Multi-omics

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