IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM.
Journal for immunotherapy of cancer(2023)
摘要
We demonstrate that MDSC of the glioma TME express IL15Ra and that these cells can be targeted with secretory IL15 or an IL15Rα-targeting moiety incorporated into the CAR. Thus, IL15-modified CAR T cells act as a dual targeting agent against tumor cells and MDSC in GBM, warranting their future evaluation in early-phase clinical studies.
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关键词
Brain Neoplasms,Cell Engineering,Immunotherapy, Adoptive,Myeloid-Derived Suppressor Cells,T-Lymphocytes
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