Severity and intractableness of skin infections caused by Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY(2023)
Abstract
Cases of skin infections caused by Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA), particularly USA300 clone, have been increasing in Japan. We report that clinical findings of 5 patients with PVL-positive MRSA and compared to those of four patients with PVL-negative MRSA. Severities of patients with PVL-positive MRSA were significantly higher than those of patients with PVL-negative MRSA. Average durations of antimicrobial therapy for patients with PVL-positive MRSA were 3.4-fold longer than those for patients with PVL-negative MRSA. Our data suggest that PVL-positive MRSA should be deal with a causative agent for intractable skin infections in Japan likewise other countries.
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Key words
methicillin-resistant Staphylococcus aureus,Panton-Valentine leukocidin,USA300
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