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Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages

Namal Perera,Feng-Ling Yang,Ching-Ming Chang,Yueh-Tung Lu, Shih-Hao Zhan,Yi-Ting Tsai,Jung-Feng Hsieh,Lan-Hui Li,Kuo-Feng Hua,Shih-Hsiung Wu

ORGANIC LETTERS（2017）

Cited 17|Views19
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Abstract
Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Taiwan medicinal mushroom Antrodia cinnamomea, and its chemical structure was determined herein. ACP significantly enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.
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Key words
macrophages,phagocytic activity,galactomannan
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