HuD regulates the cpg15 expression via its 3'-UTR

Abstract： The candidate plasticity related gene 15 (cpg15) plays important roles in neural development and plasticity. In the present study, we studied the role of the cpg15 3'-untranslated region (UTR) in regulating the expression of the gene. The results showed that the presence of the 3'-UTR significantly decreases, while the absence of the 3'-UTR increases the cpg15 expression, indicating that the 3'-UTR may be critical for regulation of cpg15 expression. In addition, HuD, a neural-specific RNA binding protein, increased the cpg15 expression, which depends on the presence of the 3'-UTR. The results suggest that HuD regulates the cpg15 expression via the 3'-UTR-mediated mechanism.