Case-controlled study of acute non-variceal upper gastrointestinal bleeding-induced coagulation dysfunction

Objective: To investigate whether coagulation dysfunction exists in patients with acute non- variceal upper gastrointestinal bleeding (ANVUGIB) and whether there may be any change in the coagulation function when the Rockall scores are different. Methods: A total of 364 ANVUGIB patients were selected and divided into the high-risk group (>= 5 points, H), the intermediate-risk group (3-4 points, I), and thelow-risk group (0-2 points, L) according to the Rockall scores. The coagulation/ fibrinolysis markers were detected in all participants, together with healthy controls selected during the same period. Results: In general, the differences in prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), D-dimer (D-D), and Ca2+ between ANVUGIB patients and healthy controls were statistically significant (P<0.05). There was statistical significance in PT, INR, APTT, and Ca2+ among the groups with different Rockall scores (P<0.05). There was a negative correlation between Ca2+ and Rockall score in group L (P< 0.05, r=-0.196) while a positive correlation between D-D and Rockall score in group H (P<0.05, r=0.509). Conclusions: PT, INR, APTT, FIB, D- D, and Ca2+, which are commonly used in laboratory, can be used as effective markers for the diagnosis and treatment of patients with ANVUGIB-caused coagulopathy.