Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome.

Hypertension is a cardiovascular disease that seriously threat-ens public health worldwide.Early and effective control of blood pressure can prevent the occurrence of stroke,coronary heart dis-ease,kidney disease,etc.[1,2].The influence of genetic factors on hypertension has been confirmed multiple times,and targeted medication according to genetic testing remains a challenge for hypertension treatment at present[3].