The effects of leaflet material properties on the simulated function of regurgitant mitral valves
arxiv(2023)
摘要
Advances in three-dimensional imaging provide the ability to construct and
analyze finite element (FE) models to evaluate the biomechanical behavior and
function of atrioventricular valves. However, while obtaining patient-specific
valve geometry is now possible, non-invasive measurement of patient-specific
leaflet material properties remains nearly impossible. Both valve geometry and
tissue properties play a significant role in governing valve dynamics, leading
to the central question of whether clinically relevant insights can be attained
from FE analysis of atrioventricular valves without precise knowledge of tissue
properties. As such we investigated 1) the influence of tissue extensibility
and 2) the effects of constitutive model parameters and leaflet thickness on
simulated valve function and mechanics. We compared metrics of valve function
(e.g., leaflet coaptation and regurgitant orifice area) and mechanics (e.g.,
stress and strain) across one normal and three regurgitant mitral valve (MV)
models with common mechanisms of regurgitation (annular dilation, leaflet
prolapse, leaflet tethering) of both moderate and severe degree. We developed a
novel fully-automated approach to accurately quantify regurgitant orifice areas
of complex valve geometries. We found that the relative ordering of the
mechanical and functional metrics was maintained across a group of valves using
material properties up to 15
constitutive model. Our findings suggest that FE simulations can be used to
qualitatively compare how differences and alterations in valve structure affect
relative atrioventricular valve function even in populations where material
properties are not precisely known.
更多查看译文
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要