Pediatric Philadelphia-Negative Myeloproliferative Neoplasms in the Era of WHO Classification: A Systematic Review.

Abdulrahman F Al-Mashdali,Mahmood B Aldapt,Alaa Rahhal,Yousef M Hailan, Israa Elhakeem,Elrazi A Ali,Waail Rozi,Mohamed A Yassin

Diagnostics (Basel, Switzerland)（2023）

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Abstract

Given the rarity of MPNs in pediatrics and their different characteristics compared with adults, we believe there is a need for unique diagnostic criteria to match the different molecular statuses in pediatrics. Based on our review, the incidence of MPN complications in pediatrics, including thrombotic events, hemorrhage, and leukemic transformation, differs from that in adults.

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Key words

MPN,essential thrombocythemia,myeloproliferative neoplasms,pediatrics,polycythemia vera,primary myelofibrosis

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