Repurposing the Bis-Biguanide Alexidine in Combination with Tyrosine Kinase Inhibitors to Eliminate Leukemic Stem/Progenitor Cells in Chronic Myeloid Leukemia.

Fabien Muselli,Lucas Mourgues,Nathalie Rochet,Marielle Nebout,Agnès Guerci,Els Verhoeyen,Adrien Krug,Laurence Legros,Jean-François Peyron,Didier Mary

Cancers（2023）

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摘要

Collectively, our results validate the use of ALX bis-biguanide to potentiate the action of conventional TKI treatment as a potential new therapeutic solution to eradicate CML LSCs.

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关键词

BMI1,alexidine,apoptosis,chronic myeloid leukemia,leukemic stem/progenitor cells,oxidative metabolism

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