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The liver-kidney axis: Is serum leptin a potential link in non-alcoholic fatty liver disease-associated chronic kidney disease?

Mustafa Canbakan,Oguz Kagan Bakkaloglu,Kadri Atay,Emine Koroglu, Mehmet Murat Tuncer,Billur Canbakan,Hakan Senturk

Arab Journal of Gastroenterology（2023）

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Abstract
Advanced fibrosis in NAFLD patients is a risk factor for CKD. Leptin correlated inversely with advanced fibrosis. Unlike the previous studies, which were not performed in NAFLD patients, we found decreased leptin in NAFLD patients with decreased eGFR. Low leptin level was found to be a dependent predictor for differentiating NAFLD patients with high risk for CKD.
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Key words
Non-alcoholic fatty liver disease,Chronic kidney disease,Leptin,eGFR,MDRD
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