A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates

Henrique Chapola,Marco Antônio de Bastiani, Marcelo Mendes Duarte, Matheus Becker Freitas, Jussara Severo Schuster,Daiani Machado de Vargas,Fábio Klamt

Virus Research（2023）

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摘要

•The molecular signature of severe COVID-19 in lung autopsies was stablished.•Six transcription factors were found as Master Regulators for COVID-19 severe form.•52 drugs were proposed as reversers of the severe COVID-19 molecular signature.•A limited overlap between clinical and pre-clinical COVID-19 data was identified.

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关键词

COVID-19,Drug repositioning,Master regulators,Disease signature

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