Three new pentacyclic triterpenes isolated from Strychnos henningsii Gilg. and their cytotoxic evaluation

Three new pentacyclic triterpenes, henninglupal (), 19-ethylene henningsyl (), and 19-ethylene henningsal (), along with the previously reported crystal heninngsal () and alpha-amyrin acetate () were isolated from a methanolic extract of the bark of Gilg. The new pentacyclic triterpenes were elucidated through comprehensive spectroscopic analysis, including 1D, 2D NMR, and High-resolution LCMS. The MTT cytotoxicity of compound - was evaluated on Caco-2 cell lines, where all the isolated compounds exhibited low cytotoxic effects up to concentrations of 125 µM.