Surf4 (Surfeit Locus Protein 4) Deficiency Reduces Intestinal Lipid Absorption and Secretion and Decreases Metabolism in Mice.

Geru Tao,Hao Wang,Yishi Shen,Lei Zhai,Boyan Liu,Bingxiang Wang,Wei Chen,Sijie Xing,Yuan Chen,Hong-Mei Gu,Shucun Qin,Da-Wei Zhang

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Our findings demonstrate that intestinal Surf4 plays an essential role in lipid absorption and chylomicron secretion and suggest that the therapeutic use of Surf4 inhibition requires highly cell/tissue-specific targeting.

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关键词

COPII,chylomicrons,enterocytes,liver,sex difference

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