SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1.

Zhi-Hua Xiao,Zheng-Yuan Xie,Qing Wang,Hui Lu,Heng-Wei Cao

Immunobiology（2023）

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摘要

This study proved that SIRT7 can directly target the K86R site of HMGB1 and participate in regulating the expression and distribution of HMGB1, thus affecting the autophagy and activation level of HSCs.

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关键词

Activation,Autophagy,HMGB1,Hepatic fibrosis,SIRT7

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