Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models.

European heart journal（2023）

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摘要

Targeting ATIC-mediated DNPS compromises the availability of purine nucleotides for incorporation into DNA/RNA, reducing PASMC proliferation and pulmonary vascular remodelling and ameliorating the development and progression of PH.

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关键词

De novo purine synthesis,ATIC,Pulmonary hypertension,Vascular smooth muscle cells

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