Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion.

Iris E M de Jong,Silke B Bodewes,Otto B van Leeuwen,Dorenda Oosterhuis,Veerle A Lantinga,Adam M Thorne,Bianca Lascaris,Marius C van den Heuvel,Rebecca G Wells,Peter Olinga,Vincent E de Meijer,Robert J Porte

Transplantation（2023）

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摘要

Favorable bile chemistry during NMP correlates well with better-preserved biliary microvasculature and PBGs, with a preserved capacity for biliary regeneration. During NMP, biliary tree progenitor cells start to differentiate toward mature cholangiocytes, facilitating restoration of the ischemically damaged surface epithelium.

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