Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction.

Kristin Köhler-Forsberg,Vibeke H Dam,Brice Ozenne,Anjali Sankar,Vincent Beliveau,Elizabeth B Landman,Søren V Larsen,Asbjørn S Poulsen,Cheng-Teng Ip,Anders Jørgensen,Michal Meyer,Dea S Stenbæk,Hans R L Eiberg,Jacob Madsen,Claus Svarer,Martin B Jørgensen,Vibe G Frokjaer,Gitte M Knudsen

JAMA psychiatry（2023）

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摘要

Results of this study show that cerebral 5-HT4 receptor binding was lower in patients with MDD than in healthy controls and that the memory dysfunction in patients with MDD was associated with lower cerebral 5-HT4 receptor binding. The cerebral 5-HT4 receptor is a promising treatment target for memory dysfunction in patients with MDD.

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major depressive disorder,receptor brain binding

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