Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer.

Yves Boucher,Jessica M Posada,Sonu Subudhi,Ashwin S Kumar,Spencer R Rosario,Liqun Gu,Heena Kumra,Mari Mino-Kenudson,Nilesh P Talele,Dan G Duda,Dai Fukumura, Jennifer Y Wo,Jeffrey W Clark,David P Ryan, Carlos Fernandez-Del Castillo,Theodore S Hong,Mikael J Pittet,Rakesh K Jain

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Adding LOS to FFX+CRT reduced pro-invasion and immunosuppression-related genes, which were associated with improved OS in patients with LAPC. Lesions from responders in the LOS+FFX+CRT-treated group had reduced Tregs, decreased C-FOXP3 and increased CD8+ T cells. These findings suggest that LOS may potentiate the benefit of FFX+CRT by reducing immunosuppression.

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关键词

pancreatic cancer,cancer cells,chemoradiation,losartan,immunosuppression-associated

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