S100A6 participates in initiation of autoimmune encephalitis and is under epigenetic control.

Chih-Hsiang Lin,Sung-Chou Li,Ming-Hong Lin,Chen-Jui Ho,Yan-Ting Lu,Yuyu Lin,Pei-Hsien Lin,Kuo-Wang Tsai,Meng-Han Tsai

Brain and behavior（2023）

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摘要

We clarified that S100A6 was under epigenetic regulation in patients with AE and that it helped B lymphocytes to adhere to and infiltrate the BBB endothelial layer, which could be counteracted by S100A6 antibodies. Therefore, the methylation profile of S100A6 could be a marker of the activity of AE, and countering the effect of S100A6 may be a potential treatment target for AE.

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关键词

B lymphocyte infiltration,DNA methylation,S100A6,autoimmune encephalitis,leukocyte-endothelial adhesion

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