4-nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen-independent Prostate Cancer Cells.

Gabriela da Silva Guimarães,Antonielle Oliveira Cordeiro,Matheus Coutinho Gazolla,Lara Vecchi,Mariana Alves Pereira Zoia,Fernanda Van Petten de Vasconcelos Azevedo, Igor Moreira Campos,Danilo de Souza Costa,Sara Teixeira Soares Mota,Matheus Alves Ribeiro,Luiz Ricardo Goulart,Ademar Alves da Silva Filho,Thaise Gonçalves Araújo

Current topics in medicinal chemistry（2023）

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摘要

Collectively, these data demonstrated, for the first time, that the combination of 4-NC with reduced doses of DOC could be especially valuable in the suppression of oncogenic mechanisms of androgen-independent PCa cells.

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关键词

Androgen-independent prostate cancer,Chemotherapy,Epithelial-mesenchymal transition,Natural products,Synergistic,Treatment

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