Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet β cells.

Xiuhong Lin,Lin Cheng,Yan Wan,Yuerong Yan, Zhuo Zhang,Xiaohui Li,Jiayun Wu, Xiaoyi Wang,Mingtong Xu

Endocrine, metabolic & immune disorders drug targets（2023）

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摘要

The effects of Ang II on mouse islet β cells were mediated by miR-375 through miR-375/Mapkap 1 axis. This targeted regulation may occur by affecting Akt phosphorylation of β cells. These results may provide new ideas and a scientific basis for further development of miRNA-targeted islet protection measures.

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关键词

Angiotensin II,Mapkap1,RAS,cells,islet ?,miR-375

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