Perivascular signals drive microglial appetite
Nature neuroscience(2023)
摘要
Microglial synapse engulfment precedes brain amyloid plaque formation and probably contributes to early cognitive decline in Alzheimer’s disease. The mechanisms that regulate microglia-mediated synapse engulfment are unclear. De Schepper et al. show that perivascular SPP1 induces microglia-mediated synapse engulfment, highlighting a neuroimmune interaction that contributes to synapse loss in amyloid pathology.
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关键词
Alzheimer's disease,Microglia,Neuroimmunology,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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