A mathematical model for assessing shear induced bleeding risk.

Yuan Li,Hongyu Wang,Yifeng Xi,Anqiang Sun,Lizhen Wang,Xiaoyan Deng,Zengsheng Chen,Yubo Fan

Computer methods and programs in biomedicine（2023）

Cited 2|Views7

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Abstract

In this study, the shear-induced bleeding risk predicted by our bleeding model in axial flow-through Couette device and two clinical VADs is consistent or highly correlated with experimental and clinical findings, which proves the accuracy of our bleeding model. Our bleeding model can be used to aid the development of new BCMDs with improved functional characteristics and biocompatibility, and help to reduce risk of device-induced adverse events in patients.

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Key words

Bleeding,Blood contact medical devices,Platelet receptors,Shear stress,VAD,vWF

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